Synergistic Effects of Combined Treatments with Oral Zinc Sulfate and Dietary Moringa oleifera Leaf Powder on Body Weight, Blood Glucose, and Lipid Profile in Streptozotocin-Induced Diabetic Rats

Authors

  • A. I. Ganiyu, A. P. Yusuf, A. Muntari, S. Kabir, B. Abdulrahman, L. Nura, M. Aliyu, M. B. Abubakar, A. Muhammad and A. S. Idoko Department of Biochemistry and Molecular Biology, Federal University Dutsin-Ma, P.M.B 5001, Katsina State, Nigeria

Keywords:

Biochemical indices, Dyslipidemia, Hyperglycemia, Type 1 diabetes, Weight loss

Abstract

Zinc and M. oleifera have shown great antidiabetic potential individually but the therapeutic potential of their combination is underreported. This study examined the synergistic impact of oral zinc and dietary M. oleifera leaf supplementation on body weight, fasting blood glucose, and lipid profile in streptozotocin-treated diabetic rats. Fifty-six male adult Wistar rats were randomly grouped into seven as follows: (1) normal controls without treatment, (2) normal controls fed a 3% M. oleifera leaf-supplemented diet, (3) diabetic controls without treatment, (4) diabetic rats treated with 200 mg/kg oral metformin, (5) diabetic rats fed a 3% M. oleifera leaf-supplemented diet, (6) diabetic rats treated with 100 mg/kg oral zinc sulfate, and (7)  diabetic rats fed a 3% M. oleifera leaf-supplemented diet and treated with 100 mg/kg oral zinc sulfate.  The results suggest that group 3 had significant (p<0.05) weight loss, and elevated blood glucose and lipids compared to groups 1 and 2. However, when all the treated diabetic groups were compared with group 3, group 4 had a significant (p<0.05) rise in body weight; fasting blood glucose levels dropped considerably in groups 4 and 7; none of the groups (4-7) showed a significant (p<0.05) change in total cholesterol; low-density lipoproteins decreased significantly (p<0.05)  in groups 5 and 7; group 7 showed a significant (p<0.05) reduction in triglycerides and an increase in high-density lipoproteins. Conclusively, the combined supplementation with oral zinc and dietary M. oleifera generally outperformed the individual treatments with zinc or M. oleifera, indicating a possible synergistic effect of their combination.

Author Biography

A. I. Ganiyu, A. P. Yusuf, A. Muntari, S. Kabir, B. Abdulrahman, L. Nura, M. Aliyu, M. B. Abubakar, A. Muhammad and A. S. Idoko, Department of Biochemistry and Molecular Biology, Federal University Dutsin-Ma, P.M.B 5001, Katsina State, Nigeria

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Published

05/12/2024